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Paraproteinemisk polynevropati

Sist revidert:
Sist revidert av:
  1. Carroll AS, Lunn MPT. Paraproteinaemic neuropathy: MGUS and beyond. Pract Neurol. 2021 Jul 19:practneurol-2020-002837. PMID: 34282034. PubMed  
  2. Karam C, Moshe-Lilie O, Chahin N, Ragole T, Medvedova E, Silbermann R. Diagnosis of paraproteinemic neuropathy: Room for improvement. J Neurol Sci. 2020 Aug 15;415:116902. doi: 10.1016/j.jns.2020.116902. Epub 2020 May 18. PMID: 32497875. PubMed  
  3. Bonekamp D1, Hruban RH2, Fishman EK3.. The great mimickers: Castleman disease. Semin Ultrasound CT MR. 2014; Jun;35(3):: 263-71. pmid: 24929266 PubMed  
  4. Leavell Y, Shin SC. Paraproteinemias and Peripheral Nerve Disease. Clin Geriatr Med. 2021 May;37(2):301-312. PMID: 33858612. PubMed  
  5. Kieseier BC, Mathey EK, Sommer C, Hartung HP. Immune-mediated neuropathies. Nat Rev Dis Primers. 2018 Oct 11;4(1):31. doi: 10.1038/s41572-018-0027-2. PMID: 30310069. PubMed  
  6. Peillet C, Adams D, Attarian S, Bouhour F, Cauquil C, Cassereau J, Chanson JB, Cintas P, Creange A, Delmont E, Fargeot G, Genestet S, Gueguen A, Kaminsky AL, Kuntzer T, Labeyrie C, Michaud M, Pereon Y, Puma A, Viala K, Chretien P, Adam C, Echaniz-Laguna A. Anti-disialosyl-immunoglobulin M chronic autoimmune neuropathies: a nationwide multicenter retrospective study. Eur J Neurol. 2022 Aug 15. doi: 10.1111/ene.15523. Epub ahead of print. PMID: 35969369. PubMed  
  7. Lunn MP. Neuropathies and paraproteins. Curr Opin Neurol. 2019 Oct;32(5):658-665. PMID: 31313705 PubMed  
  8. Rajabally YA, Delmont E, Hiew FL, Aubé-Nathier AC, Grapperon AM, Cassereau J, Attarian S. Prevalence, correlates and impact of pain and cramps in anti-MAG neuropathy: a multicentre European study. Eur J Neurol. 2017 Sep 14 . pmid:28906575 PubMed  
  9. Svahn J, Petiot P, Antoine JC, Vial C, Delmont E, Viala K, Steck AJ, Magot A, Cauquil C, Zarea A, Echaniz-Laguna A, Iancu Ferfoglia R, Gueguen A, Magy L, Léger JM, Kuntzer T, Ferraud K, Lacour A, Camdessanché JP; Francophone anti-MAG cohort Group. Anti-MAG antibodies in 202 patients: clinicopathological and therapeutic features. J Neurol Neurosurg Psychiatry. 2017 Oct 25 . pmid:29070644 PubMed  
  10. Garcia-Santibanez R et al. CANOMAD and other chronic ataxic neuropathies with disialosyl antibodies (CANDA). J Neurol. 2018; Jun;265(6):: 1402-1409. pmid:29633012 PubMed  
  11. Yuki N, Uncini A.. Acute and chronic ataxic neuropathies with disialosyl antibodies: a continuous clinical spectrum and a common pathophysiological mechanism.. Muscle Nerve 2014; 49(5): 629-35. pmid:24477718 PubMed  
  12. Attarian S. Chronic ataxic neuropathies associated with anti-GD1b IgM antibodies: Response to IVIg therapy. J Neurol Neurosurg Psychiatry 2010; 81: 61-4. PMID: 19726417 PubMed  
  13. Grundmann A, Hardwick M, Ledingham D, Miller J. Sensory ataxia with cranial nerve palsies. Pract Neurol. 2022 Feb;22(1):85-89. PMID: 34135093. PubMed  
  14. Yuki N, Uncini A. Acute and chronic ataxic neuropathies with disialosyl antibodies: a continuous clinical spectrum and a common pathophysiological mechanism.. Muscle Nerve. 2014; May;49(5): 629-35. pmid:24477718 PubMed  
  15. Mauermann ML.. The Peripheral Neuropathies of POEMS Syndrome and Castleman Disease. Hematol Oncol Clin North Am. 2018; Feb;32(1):: 153-163. pmid:29157616 PubMed  
  16. Keddie S, Lunn MP. POEMS syndrome. Curr Opin Neurol. 2018; Oct;31(5): 551-558. pmid:551-558
  17. Suichi T et al. Proposal of new clinical diagnostic criteria for POEMS syndrome. J Neurol Neurosurg Psychiatry. 2018. pmid:30279213 PubMed  
  18. Brown R, Ginsberg. POEMS syndrome: clinical update. J Neurol. 2019; Jan;266(1: 268-277. pmid:30498913 PubMed  
  19. Li Y, Valent J, Soltanzadeh P, Thakore N, Katirji B. Diagnostic challenges in POEMS syndrome presenting with polyneuropathy: A case series. J Neurol Sci. 2017 Jul 15;378:170-174 . pmid:28566158 PubMed  
  20. Keddie S, Foldes D, Caimari F, Baldeweg SE, Bomsztyk J, Ziff OJ, Fehmi J, Cerner A, Jaunmuktane Z, Brandner S, Yong K, Manji H, Carr A, Rinaldi S, Reilly MM, D'Sa S, Lunn MP. Clinical characteristics, risk factors, and outcomes of POEMS syndrome: A longitudinal cohort study. Neurology 2020. pmid:32606227 PubMed  
  21. Ziff OJ, Hoskote C, Keddie S, D'Sa S, Davangnanam I, Lunn MPT. Frequent central nervous system, pachymeningeal and plexus MRI changes in POEMS syndrome. J Neurol. 2019 May;266(5):1067-1072. PMID: 30756171 PubMed  
  22. Placebo-controlled trial of rituximab in IgM anti-myelin-associated glycoprotein neuropathy. Léger JM, Viala K, Nicolas G, Créange A, Vallat JM, Pouget J, Clavelou P, Vial C, Steck A, Musset L, Marin B; RIMAG Study Group (France and Switzerland). Neurology. 2013 Jun 11;80(24):2217-25.PMID: 23667063 PubMed  
  23. Kapoor M et al. Diagnosis of amyloid neuropathy. Pract Neurol. 2018. pmid:30598431 PubMed  
  24. Nobile-Orazio E, Bianco M, Nozza A. Advances in the Treatment of Paraproteinemic Neuropathy. Curr Treat Options Neurol. 2017 Oct 16;19(12):43. pmid:29034435 PubMed  
  25. Campagnolo M, Zambello R, Nobile-Orazio E, Benedetti L, Marfia GA, Riva N, Castellani F, Bianco M, Salvalaggio A, Garnero M, Ruiz M, Mataluni G, Fazio R, Ermani M, Briani C. IgM MGUS and Waldenstrom-associated anti-MAG neuropathies display similar response to rituximab therapy.. J Neurol Neurosurg Psychiatry. 2017; Dec;88(12): 1094-1097. pmid:28501820 PubMed  
  26. Léger JM, Viala K, Nicolas G, Créange A, Vallat JM, Pouget J, Clavelou P, Vial C, Steck A, Musset L, Marin B; RIMAG Study Group (France and Switzerland). Placebo-controlled trial of rituximab in IgM anti-myelin-associated glycoprotein neuropathy. Neurology. 2013 Jun 11;80(24):2217-25. pmid:23667063 PubMed  
  27. Parisi M, Dogliotti I, Clerico M, Bertuzzo D, Benevolo G, Orsucci L, Schiavetti I, Cavallo R, Cavallo F, Ragaini S, Di Liberto A, Ferrante M, Bondielli G, Artusi CA, Drandi D, Lopiano L, Ferrero B, Ferrero S. Efficacy of rituximab in anti-myelin-associated glycoprotein demyelinating polyneuropathy: Clinical, hematological and neurophysiological correlations during 2 years of follow-up. Eur J Neurol. 2022 Sep 9. doi: 10.1111/ene.15553. Epub ahead of print. PMID: 3608371 PubMed  
  28. Hänggi P, Aliu B, Martin K, Herrendorff R, Steck AJ. Decrease in Serum Anti-MAG Autoantibodies Is Associated With Therapy Response in Patients With Anti-MAG Neuropathy: Retrospective Study. Neurol Neuroimmunol Neuroinflamm. 2021 Nov 10;9(1):e1109. PMID: 34759022 PubMed  
  29. Baron M, Lozeron P, Harel S, Bengoufa D, Vignon M, Asli B, Malphettes M, Parquet N, Brignier A, Fermand JP, Kubis N, Arnulf B. Plasma exchanges for severe acute neurological deterioration in patients with IgM anti-myelin-associated glycoprotein (anti-MAG) neuropathy. J Neurol. 2017 Jun;264(6):1132-1135. pmid:28484839 PubMed  
  30. Stino AM, Efebera Y. Lenalidomide-responsive anti-myelin-associated glycoprotein neuropathy. Muscle Nerve. 2017 Oct;56(4):E31-E32 . pmid:28561932 PubMed  
  31. Castellani F, Visentin A, Campagnolo M, Salvalaggio A, Cacciavillani M, Candiotto C, Bertorelle R, Trentin L, Briani C. . The Bruton tyrosine kinase inhibitor ibrutinib improves anti-MAG antibody polyneuropathy. Neurol Neuroimmunol Neuroinflamm 2020. pmid:32284437 PubMed  
  32. Koike H, Katsuno M. Paraproteinemia and neuropathy. Neurol Sci. 2021 Nov;42(11):4489-4501. PMID: 34529193. PubMed  
  33. Khouri J, Nakashima M, Wong S. Update on the Diagnosis and Treatment of POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal Gammopathy, and Skin Changes) Syndrome: A Review. JAMA Oncol. 2021 Sep 1;7(9):1383-1391. PMID: 34081097. PubMed  
  34. Bianco M, Terenghi F, Gallia F, Nozza A, Scarale A, Fayoumi MZ, Giannotta C, Nobile-Orazio E. Clinical, electrophysiological and VEGF 2-year response after lenalidomide or stem cell transplantation in patients with POEMS syndrome. J Neurol Neurosurg Psychiatry. 2018. pmid:29945880 PubMed  
  35. Sekiguchi Y, Misawa S, Shibuya K, Nasu S, Mitsuma S, Iwai Y, Beppu M, Sawai S, Ito S, Hirano S, Nakaseko C, Kuwabara S. Ambiguous effects of anti-VEGF monoclonal antibody (bevacizumab) for POEMS syndrome. J Neurol Neurosurg Psychiatry 2013; Dec;84(12): 1346-8. pmid:23463868 PubMed  
  36. Gupta A, Kumar PS, Puri V, Saran RK, Narang P, Chowdhury D. 51-year old man with tingling, burning and progressive limb weakness. Pract Neurol. 2018 Oct;18(5):382-388. PMID: 31091191 PubMed  
  • Åse Mygland, spesialist i nevrologi, professor dr med
  • Unn Ljøstad, spesialist i nevrolgi, profesor PhD
  • Christian Vedeler, spesialist i nevrologi, professor dr med