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  1. Eigenbrodt AK, Ashina H, Khan S, Diener HC, Mitsikostas DD, Sinclair AJ, Pozo-Rosich P, Martelletti P, Ducros A, Lantéri-Minet M, Braschinsky M, Del Rio MS, Daniel O, Özge A, Mammadbayli A, Arons M, Skorobogatykh K, Romanenko V, Terwindt GM, Paemeleire K, Sacco S, Reuter U, Lampl C, Schytz HW, Katsarava Z, Steiner TJ, Ashina M. Diagnosis and management of migraine in ten steps. Nat Rev Neurol. 2021 Aug;17(8):501-514. PMID: 34145431 PubMed  
  2. Charles A. Migraine.N Engl J Med. 2017 Oct 26;377(17):1698-1699. PMID: 29069565 PubMed  
  3. Linde M, Stovner LJ, Zwart JA, Hagen K.Time trends in the prevalence of headache disorders. The Nord-Trondelag Health Studies (HUNT 2 and HUNT 3).Cephalalgia. 2011 Apr;31(5):585-96.
  4. Pelzer N, Haan J, Stam AH, Vijfhuizen LS, Koelewijn SC, Smagge A, de Vries B, Ferrari MD, van den Maagdenberg AMJM, Terwindt GM. Clinical spectrum of hemiplegic migraine and chances of finding a pathogenic mutation. Neurology. 2018 Jan 17. PMID: 29343472 PubMed  
  5. Diener HC, Charles A, Goadsby PJ, Holle D. New therapeutic approaches for the prevention and treatment of migraine. Lancet Neurol. 2015 Oct;14(10):1010-22 . pmid:26376968 PubMed  
  6. Sinclair AJ, Sturrock A, Davies B, Matharu M. Headache management: pharmacological approaches. Pract Neurol. 2015 Jul 3. pii: practneurol-2015-001167 . pmid:26141299 PubMed  
  7. Nestoriuc Y, Martin A, Rief W, Andrasik F. Biofeedback treatment for headache disorders: a comprehensive efficacy review. Appl Psychophysiol Biofeedback 2008; 33: 125-40. pmid:18726688 PubMed  
  8. Xu S, Yu L, Luo X, Wang M, Chen G, Zhang Q, Liu W, Zhou Z, Song J, Jing H, Huang G, Liang F, Wang H, Wang W. Manual acupuncture versus sham acupuncture and usual care for prophylaxis of episodic migraine without aura: multicentre, randomised clinical trial. BMJ. 2020 Mar 25;368:m697. doi: 10.1136/bmj.m697. PMID: 32213509 PubMed  
  9. Linde K, Allais G, Brinkhaus B, Manheimer E, Vickers A, White AR. Acupuncture for migraine prophylaxis. Cochrane Database Syst Rev. 2009; 21: CD001218. Cochrane (DOI)  
  10. Kumar A, Bhatia R, Sharma G, Dhanlika D, Vishnubhatla S, Singh RK, Dash D, Tripathi M, Srivastava MVP. Effect of yoga as add-on therapy in migraine (CONTAIN): A randomized clinical trial. Neurology. 2020 May 26;94(21):e2203-e2212. doi: 10.1212/WNL.0000000000009473. Epub 2020 May 6. PMID: 32376640. PubMed  
  11. Evans AG, Horrar AN, Ibrahim MM, Burns BL, Kalmar CL, Assi PE, Brooks-Horrar KN, Kesayan T, Al Kassis S. Outcomes of transcutaneous nerve stimulation for migraine headaches: a systematic review and meta-analysis. J Neurol. 2022 Aug;269(8):4021-4029. doi: 10.1007/s00415-022-11059-1. Epub 2022 Mar 16. PMID: 35296960. PubMed  
  12. Miller S.The acute and preventative treatment of episodic migraine.Ann Indian Acad Neurol. 2012 Aug;15(Suppl 1):S33-9.PMID:23024562 PubMed  
  13. VanderPluym JH, Halker Singh RB, Urtecho M, Morrow AS, Nayfeh T, Torres Roldan VD, Farah MH, Hasan B, Saadi S, Shah S, Abd-Rabu R, Daraz L, Prokop LJ, Murad MH, Wang Z. Acute Treatments for Episodic Migraine in Adults: A Systematic Review and Meta-analysis. JAMA. 2021 Jun 15;325(23):2357-2369. PMID: 34128998 PubMed  
  14. Marmura MJ, Silberstein SD, Schwedt TJ. The acute treatment of migraine in adults: the american headache society evidence assessment of migraine pharmacotherapies. Headache 2015; 55: 3-20. pmid:25600718 PubMed  
  15. Kirthi V, Derry S, Moore RA. Aspirin with or without an antiemetic for acute migraine headaches in adults. Cochrane Database Syst Rev. 2013 Apr 30;4:CD008041. doi: 10.1002/14651858.CD008041.pub3. PMID: 23633350 PubMed  
  16. Derry S, Moore RA. Paracetamol (acetaminophen) with or without an antiemetic for acute migraine headaches in adults. Cochrane Database Syst Rev. 2013 Apr 30;4:CD008040. doi: 10.1002/14651858.CD008040.pub3. PMID: 23633349 PubMed  
  17. Ferrari MD, Roon KI, Lipton RB, Goadsby PJ. Oral triptans (serotonin 5-HT(1B/1D) agonists) in acute migraine treatment: a meta-analysis of 53 trials. Lancet 2001; 358: 1668-75. pmid:11728541 PubMed  
  18. Evers S, Afra J, Frese A, Goadsby PJ, Linde M, May A, Sándor PS. EFNS guideline on the drug treatment of migraine--revised report of an EFNS task force.Eur J Neurol. 2009 Sep;16(9):968-81. doi: 10.1111/j.1468-1331.2009.02748.x. DOI  
  19. Brandes JL, Kudrow D, Stark SR, O'Carroll CP, Adelman JU, O'Donnell FJ, Alexander WJ, Spruill SE, Barrett PS, Lener SE. Sumatriptan-naproxen for acute treatment of migraine: a randomized trial. JAMA 2007; 297: 1443-54. pmid:17405970 PubMed  
  20. Laurell K, Artto V, Bendtsen L, Hagen K, Kallela M, Meyer EL, Putaala J, Tronvik E, Zwart JA, Linde M. Migrainous infarction: a Nordic multicenter study. Eur J Neurol 2011; 18: 1220-6. pmid:21414105 PubMed  
  21. Roberto G, Piccinni C, D'Alessandro R, Poluzzi E. Triptans and serious adverse vascular events: Data mining of the FDA Adverse Event Reporting System database. Cephalalgia. 2013 Aug 6. Epub ahead of print PMID: 23921799 PubMed  
  22. Artto V, Nissilä M, Wessman M, Palotie A, Färkkilä M, Kallela M. Treatment of hemiplegic migraine with triptans. Eur J Neurol 2007; 14: 1053-6. PubMed  
  23. Klapper J, Mathew N, Nett R. Triptans in the treatment of basilar migraine and migraine with prolonged aura. Headache. 2001 Nov-Dec;41(10):981-4. PMID: 11903526 PubMed  
  24. MacGregor EA. A review of frovatriptan for the treatment of menstrual migraine. Int J Womens Health. 2014. doi:10.2147/IJWH.S63444 DOI  
  25. Colman I, Brown MD, Innes GD, Grafstein E, Roberts TE, Rowe BH.. Parenteral metoclopramide for acute migraine: meta-analysis of randomised controlled trials.. BMJ. 2004; Dec 11;329(7479):: 1369-73. pmid:15550401 PubMed  
  26. Doğan NÖ, Pekdemir M, Yılmaz S, Yaka E, Karadaş A, Durmuş U, Avcu N, Koçkan E.. Intravenous metoclopramide in the treatment of acute migraines: A randomized, placebo-controlled trial.. Acta Neurol Scand 2019; Apr;139(4):: 334-339. pmid:30629285 PubMed  
  27. Friedman BW1, Garber L, Yoon A, Solorzano C, Wollowitz A, Esses D, Bijur PE, Gallagher EJ.. Randomized trial of IV valproate vs metoclopramide vs ketorolac for acute migraine. Neurology. 2014; Mar 18;82(11): 976-83. pmid:24523483 PubMed  
  28. Ketorolac in the treatment of acute migraine: a systematic review. Headache 2013 ; Feb;53(2):: 277-87. pmid:23298250 PubMed  
  29. Friedman BW, Irizarry E, Solorzano C, Latev A, Rosa K, Zias E, Vinson DR, Bijur PE, Gallagher EJ. Randomized study of IV prochlorperazine plus diphenhydramine vs IV hydromorphone for migraine. Neurology. 2017 Nov 14;89(20):2075-2082. PMID: 29046364 PubMed  
  30. Vécsei L, Szok D, Nyári A, Tajti J. Treating status migrainosus in the emergency setting: what is the best strategy? Expert Opin Pharmacother. 2018 Oct;19(14):1523-1531.PMID: 30198804 PubMed  
  31. Korucu O1, Dagar S2, Çorbacioglu ŞK2, Emektar E2, Cevik Y2.. The effectiveness of greater occipital nerve blockade in treating acute migraine-related headaches in emergency departments. Acta Neurol Scand. 2018; Sep;138(3):: 212-218. pmid:29744871 PubMed  
  32. Shamliyan TA, Choi JY, Ramakrishnan R, Miller JB, Wang SY, Taylor FR, Kane RL. Preventive pharmacologic treatments for episodic migraine in adults. J Gen Intern Med. 2013 Sep;28(9):1225-37. doi: 10.1007/s11606-013-2433-1. Epub 2013 Apr 17. PMID: 23592242 PubMed  
  33. Stovner LJ, Linde M, Gravdahl GB, Tronvik E, Aamodt AH, Sand T, Hagen K.. A comparative study of candesartan versus propranolol for migraine prophylaxis: A randomised, triple-blind, placebo-controlled, double cross-over study.. Cephalalgia 2013; Dec 11;34(7): 523-532. pmid:24335848 PubMed  
  34. Linde M, Mulleners WM, Chronicle EP, McCrory DC.. Topiramate for the prophylaxis of episodic migraine in adults. Cochrane Database Syst Rev. 2013 Jun 24;6:CD010610. doi: 10.1002/14651858.CD010610. PMID: 23797676 PubMed  
  35. Linde M, Mulleners WM, Chronicle EP, McCrory DC. Valproate (valproic acid and or sodium valproate) for the prophylaxis of episodic migraine in adults. Cochrane Database of Systematic Reviews 2013 CD010611. Cochrane (DOI)  
  36. Linde M, Mulleners WM, Chronicle EP, McCrory DC.. Antiepileptics other than gabapentin, pregabalin, topiramate, and valproate for the prophylaxis of episodic migraine in adults. Cochrane Database Syst Rev. 2013 Jun 24;6:CD010608. doi: 10.1002/14651858.CD010608. PMID: 23797674 PubMed  
  37. Ozyalcin SN, Talu GK, Kiziltan E, Yucel B, Ertas M, Disci R. The efficacy and safety of venlafaxine in the prophylaxis of migraine. Headache 2005; 45: 144-52. pmid:15705120 PubMed  
  38. Buettner C, Nir RR, Bertisch SM, Bernstein C, Schain A, Mittleman MA, Burstein R. Simvastatin and vitamin D for migraine prevention: A randomized, controlled trial. Ann Neurol. 2015 Dec;78(6):970-81. doi: 10.1002/ana.24534. Epub 2015 Nov 13. PMID: 26418341; PMCID: PMC4715556.
  39. Powers SW, Coffey CS, Chamberlin LA, Ecklund DJ, Klingner EA, Yankey JW, Korbee LL, Porter LL, Hershey AD; CHAMP Investigators... Trial of Amitriptyline, Topiramate, and Placebo for Pediatric Migraine.. N Engl J Med. . pmid:27788026 PubMed  
  40. Di Stefano V, et al. Diagnostic and therapeutic aspects of hemiplegic migraine. J Neurol Neurosurg Psychiatry. 2020 PMID: 32430436 PubMed  
  41. Goadsby PJ, Reuter U, Hallström Y, Broessner G, Bonner JH, Zhang F, Sapra S, Picard H, Mikol DD, Lenz RA. A Controlled Trial of Erenumab for Episodic Migraine. N Engl J Med. 2017 Nov 30;377(22):2123-2132. PMID: 29171821 PubMed  
  42. Silberstein SD, Dodick DW, Bigal ME, Yeung PP, Goadsby PJ, Blankenbiller T, Grozinski-Wolff M, Yang R, Ma Y, Aycardi E. Fremanezumab for the Preventive Treatment of Chronic Migraine. N Engl J Med. 2017 Nov 30;377(22):2113-2122. PMID: 29171818 PubMed  
  43. Steiner TJ, Buse DC, Al Jumah M, Westergaard ML, Jensen RH, Reed ML, Prilipko L, Mennini FS, Láinez MJA, Ravishankar K, Sakai F, Yu SY, Fontebasso M, Al Khathami A, MacGregor EA, Antonaci F, Tassorelli C, Lipton RB; Lifting The Burden: The Global Campaign against Headache. The headache under-response to treatment (HURT) questionnaire, an outcome measure to guide follow-up in primary care: development, psychometric evaluation and assessment of utility. J Headache Pain. 2018 Feb 14;19(1):15. doi: 10.1186/s10194-018-0842-6. PMID: 29445880 PubMed  
  44. Vernieri F, Altamura C, Brunelli N, Costa CM, Aurilia C, Egeo G, Fofi L, Favoni V, Pierangeli G, Lovati C, Aguggia M, d'Onofrio F, Doretti A, Di Fiore P, Finocchi C, Rao R, Bono F, Ranieri A, Albanese M, Cevoli S, Barbanti P; GARLIT Study Group. Galcanezumab for the prevention of high frequency episodic and chronic migraine in real life in Italy: a multicenter prospective cohort study (the GARLIT study). J Headache Pain. 2021 May 3;22(1):35. PMID: 33941080 PubMed  
  45. Pijpers JA, Kies DA, Louter MA, van Zwet EW, Ferrari MD, Terwindt GM. Acute withdrawal and botulinum toxin A in chronic migraine with medication overuse: a double-blind randomized controlled trial. Brain. 2019 May 1;142(5):1203-1214. PMID: 30982843 PubMed  
  46. Dodick DW, Turkel CC, DeGryse RE, Aurora SK, Silberstein SD, Lipton RB, Diener HC, Brin MF. OnabotulinumtoxinA for treatment of chronic migraine: pooled results from the double-blind, randomized, placebo-controlled phases of the PREEMPT clinical program.; PREEMPT Chronic Migraine Study Group.Headache. 2010 Jun;50(6):921-36. doi: 10.1111/j.1526-4610.2010.01678.x. Epub 2010 May 7.PMID:20487038 PubMed  
  47. Silberstein SD, Blumenfeld AM, Cady RK, Turner IM, Lipton RB, Diener HC, Aurora SK, Sirimanne M, DeGryse RE, Turkel CC, Dodick DW. OnabotulinumtoxinA for treatment of chronic migraine: PREEMPT 24-week pooled subgroup analysis of patients who had acute headache medication overuse at baseline. J Neurol Sci. 2013 Aug 15;331(1-2):48-56. doi: 10.1016/j.jns.2013.05.003. Epub 2013 Jun 19. PMID: 23790235 PubMed  
  48. Aurora SK, Dodick DW, Diener HC, DeGryse RE, Turkel CC, Lipton RB, Silberstein SD.. OnabotulinumtoxinA for chronic migraine: efficacy, safety, and tolerability in patients who received all five treatment cycles in the PREEMPT clinical program.. Acta Neurol Scand. 2014; Jan;129(1):: 61-70. pmid:24107267 PubMed  
  49. Bendtsen L1, Sacco S2, Ashina M3, Mitsikostas D4, Ahmed F5, Pozo-Rosich P6,7, Martelletti P8.. Guideline on the use of onabotulinumtoxinA in chronic migraine: a consensus statement from the European Headache Federation. J Headache Pain. 2018. pmid:30259200 PubMed  
  50. Velásquez-Rimachi V, Chachaima-Mar J, Cárdenas-Baltazar EC, Loayza-Vidalon A, Morán-Mariños C, Pacheco-Barrios K, Posso M, Alva-Díaz C. Greater occipital nerve block for chronic migraine patients: A meta-analysis. Acta Neurol Scand. 2022 Aug;146(2):101-114. doi: 10.1111/ane.13634. Epub 2022 Jun 21. PMID: 35726455 PubMed  
  51. Inan LE, Inan N, Karadaş Ö, Gül HL, Erdemoğlu AK, Türkel Y, Akyol A. Greater occipital nerve blockade for the treatment of chronic migraine: a randomized, multicenter, double-blind, and placebo-controlled study. Acta Neurol Scand 2015. pmid:25765043 PubMed  
  52. Reuter U, McClure C, Liebler E, Pozo-Rosich P. Non-invasive neuromodulation for migraine and cluster headache: a systematic review of clinical trials. J Neurol Neurosurg Psychiatry. 2019 Jul;90(7):796-804. PMID: 30824632 PubMed  
  53. Vukovic Cvetkovic V, Jensen RH.. Neurostimulation for the treatment of chronic migraine and cluster headache.. Acta Neurol Scand. 2019; Jan;139(1): 4-17. pmid:30291633 PubMed  
  54. Reuter U1, McClure C2, Liebler E3, Pozo-Rosich P4,5.. Non-invasive neuromodulation for migraine and cluster headache: a systematic review of clinical trial. J Neurol Neurosurg Psychiatry. 2019. pmid:30824632 PubMed  
  55. Hagen K, Stovner LJ. Treatment of migraine during pregnancy and breast feeding. Tidsskr Nor Laegeforen 2006; 126: 3107-9. pmid:17160116 PubMed  
  56. Amundsen S, Nordeng H, Nezvalová-Henriksen K, Stovner LJ, Spigset O. Pharmacological treatment of migraine during pregnancy and breastfeeding. Nat Rev Neurol 2015. pmid:25776823 PubMed  
  57. Fox AW, Chambers CD, Anderson PO, Diamond ML, Spierings EL. Evidence-based assessment of pregnancy outcome after sumatriptan exposure. Headache 2002; 42: 8-15. pmid:12005279 PubMed  
  58. Hilaire ML, Cross LB, Eichner SF. Treatment of migraine headaches with sumatriptan in pregnancy. Ann Pharmacother 2004; 38: 1726-30. pmid:15316107 PubMed  
  59. Cassina M, Di Gianantonio E, Toldo I, Battistella PA, Clementi M. Migraine therapy during pregnancy and lactation. Expert Opin Drug Saf 2010; 9: 937-48. pmid:20662551 PubMed  
  60. Macgregor EA. Headache in pregnancy. Continuum (Minneap Minn.) 2014. pmid:24492815 PubMed  
  61. Worthington I, Pringsheim T, Gawel MJ, Gladstone J, Cooper P, Dilli E, Aube M, Leroux E, Becker WJ; Canadian Headache Society Acute Migraine Treatment Guideline Development Group. Canadian Headache Society Guideline: acute drug therapy for migraine headache. Can J Neurol Sci 2013; 40: (5 Suppl 3):S1-S80. pmid:23968886 PubMed  
  62. Spigset O, Hägg S. Analgesics and breast-feeding: safety considerations. Paediatr Drugs 2000 ; 2: 223-38. pmid:10937472 PubMed  
  63. Wojnar-Horton RE, Hackett LP, Yapp P, Dusci LJ, Paech M, Ilett KF. Distribution and excretion of sumatriptan in human milk. Br J Clin Pharmacol 1996; 41: 217-21. pmid:8866921 PubMed  
  64. Hendrickson RG, McKeown NJ. Is maternal opioid use hazardous to breast-fed infants?. Clin Toxicol (Phila) 2012; 50: 1-14. pmid:22148986 PubMed  
  65. Pringsheim T, Davenport W, Mackie G, Worthington I, Aubé M, Christie SN, Gladstone J, Becker WJ; Canadian Headache Society Prophylactic Guidelines Development Group. Canadian Headache Society guideline for migraine prophylaxis. Can J Neurol Sci 2012; 39: (2 Suppl 2):S1-59. pmid:22683887 PubMed  
  66. Ahonen K, Hämäläinen ML, Rantala H, Hoppu K. Nasal sumatriptan is effective in treatment of migraine attacks in children: A randomized trial. Neurology 2004; 62: 883-7. pmid:15037686 PubMed  
  67. Evers S, Rahmann A, Kraemer C, Kurlemann G, Debus O, Husstedt IW, Frese A. Treatment of childhood migraine attacks with oral zolmitriptan and ibuprofen. Neurology 2006; 67: 497-9. pmid:16775229 PubMed  
  68. Lewis DW, Winner P, Hershey AD, Wasiewski WW; Adolescent Migraine Steering Committee. Efficacy of zolmitriptan nasal spray in adolescent migraine. Pediatrics 2007; 120: 390-6. pmid:17671066 PubMed  
  69. Ahonen K, Hämäläinen ML, Eerola M, Hoppu K. A randomized trial of rizatriptan in migraine attacks in children. Neurology 2006; 67: 1135-40. pmid:16943370 PubMed  
  70. Lewis D1, Ashwal S, Hershey A, Hirtz D, Yonker M, Silberstein S; American Academy of Neurology Quality Standards Subcommittee; Practice Committee of the Child Neurology Society. Practice parameter: pharmacological treatment of migraine headache in children and adolescents: report of the American Academy of Neurology Quality Standards Subcommittee and the Practice Committee of the Child Neurology Society. Neurology 2004; 63: 2215-24. pmid:15623677 PubMed  
  71. Winner P, Gendolla A, Stayer C, Wang S, Yuen E, Battisti WP, Nye JS. Topiramate for migraine prevention in adolescents: a pooled analysis of efficacy and safety. Headache 2006; 46: 1503-10. pmid:17115983 PubMed  
  72. Powers SW, Kashikar-Zuck SM, Allen JR, LeCates SL, Slater SK, Zafar M, Kabbouche MA, O'Brien HL, Shenk CE, Rausch JR, Hershey AD. Cognitive behavioral therapy plus amitriptyline for chronic migraine in children and adolescents: a randomized clinical trial. JAMA 2013; 310: 2622-30. pmid:24368463 PubMed  
  73. https://www.uptodate.com/contents/preventive-treatment-of-episodic-migraine-in-adults?search=preventive%20treatment%20of%20episodic%20migraine%20in%20adults&source=search_result&selectedTitle=1~150&usage_type=default&display_rank=1 UpToDate  
  74. Schürks M, Rist PM, Bigal ME, Buring JE, Lipton RB, Kurth T. Migraine and cardiovascular disease: systematic review and meta-analysis. BMJ 2009; 339: b3914 . BMJ (DOI)  
  75. Li L, Schulz UG, Kuker W, Rothwell PM; Oxford Vascular Study.. Age-specific association of migraine with cryptogenic TIA and stroke: Population-based study. Neurology. 2015 Oct 27;85(17):1444-51 . pmid:26423431 PubMed  
  76. Bandoli G et al. Migraines During Pregnancy and the Risk of Maternal Stroke. JAMA Neurol. 2020. PMID: 32478828 PubMed  
  77. Øie LR et al. Migraine and risk of stroke. J Neurol Neurosurg Psychiatry. 2020. PMID: 32217787 PubMed  
  • Mattias Linde, spesialist i nevrologi, professor PhD
  • Unn Ljøstad, spesialist i nevrologi, professor PhD
  • Åse Mygland, spesialist i nevrologi, professor dr med