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Sekundærprofylakse ved hjerneslag/TIA

Sist oppdatert: Sist revidert:
Sist revidert av:
  1. Best JG, Cardus B, Klijn CJM, Lip G, Seiffge DJ, Smith EE, Werring DJ. Antithrombotic dilemmas in stroke medicine: new data, unsolved challenges. J Neurol Neurosurg Psychiatry. 2022 Jun 21:jnnp-2020-325249. doi: 10.1136/jnnp-2020-325249. Epub ahead of print. PMID: 35728935 PubMed  
  2. Kernan WN, Ovbiagele B, Black HR, Bravata DM, Chimowitz MI, Ezekowitz MD, Fang MC, Fisher M, Furie KL, Heck DV, Johnston SC, Kasner SE, Kittner SJ, Mitchell PH, Rich MW, Richardson D, Schwamm LH, Wilson JA. Guidelines for the Prevention of Stroke in Patients With Stroke and Transient Ischemic Attack: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association. Stroke 2014. pmid:24788967 PubMed  
  3. Hao Q, Tampi M, O'Donnell M, Foroutan F, Siemieniuk RA, Guyatt G. Clopidogrel plus aspirin versus aspirin alone for acute minor ischaemic stroke or high risk transient ischaemic attack: systematic review and meta-analysis. BMJ. 2018 Dec 18;363:k5108. PMID: 30563866 PubMed  
  4. Johnston SC, Easton JD, Farrant M, Barsan W, Conwit RA, Elm JJ, Kim AS, Lindblad AS, Palesch YY; Clinical Research Collaboration, Neurological Emergencies Treatment Trials Network, and the POINT Investigators. Clopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA. N Engl J Med. 2018 Jul 19;379(3):215-225. PMID: 29766750 PubMed  
  5. Johnston SC, Amarenco P, Aunes M, Denison H, Evans SR, Himmelmann A, Jahreskog M, James S, Knutsson M, Ladenvall P, Molina CA, Nylander S, Röther J, Wang Y; THALES Investigators. Ischemic Benefit and Hemorrhage Risk of Ticagrelor-Aspirin Versus Aspirin in Patients With Acute Ischemic Stroke or Transient Ischemic Attack. Stroke. 2021 Sep 3:STROKEAHA121035555. PMID: 34477459. PubMed  
  6. Johnston SC, Amarenco P, Denison H, Evans SR, Himmelmann A, James S, Knutsson M, Ladenvall P, Molina CA, Wang Y; THALES Investigators. Ticagrelor and Aspirin or Aspirin Alone in Acute Ischemic Stroke or TIA. N Engl J Med. 2020 Jul 16;383(3):207-217. PMID: 32668111.
  7. Prasad K, Siemieniuk R, Hao Q, Guyatt G, O'Donnell M, Lytvyn L, Heen AF, Agoritsas T, Vandvik PO, Gorthi SP, Fisch L, Jusufovic M, Muller J, Booth B, Horton E, Fraiz A, Siemieniuk J, Fobuzi AC, Katragunta N, Rochwerg B. Dual antiplatelet therapy with aspirin and clopidogrel for acute high risk transient ischaemic attack and minor ischaemic stroke: a clinical practice guideline. BMJ. 2018 Dec 18;363:k5130. Erratum in: BMJ. 2019 Jan 10;364:l103. PMID: 30563885 PubMed  
  8. Johnston SC, Easton JD, Farrant M, Barsan W, Conwit RA, Elm JJ, Kim AS, Lindblad AS, Palesch YY; Clinical Research Collaboration, Neurological Emergencies Treatment Trials Network, and the POINT Investigators.. Clopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA.. N Engl J Med 2018 ; Jul 19;379(3): 215-225.. pmid:29766750 PubMed  
  9. Prasad K1, Siemieniuk R2,3, Hao Q2,4, Guyatt G2,5, O'Donnell M6, Lytvyn L2, Heen AF7, Agoritsas T2,8, Vandvik PO7,9, Gorthi SP10, Fisch L11, Jusufovic M12, Muller J13,14, Booth B13, Horton E15, Fraiz A, Siemieniuk J16, Fobuzi AC17, Katragunta N18, Rochwerg B19,5.. Dual antiplatelet therapy with aspirin and clopidogrel for acute high risk transient ischaemic attack and minor ischaemic stroke: a clinical practice guideline.. BMJ. 2018. pmid:30563885 PubMed  
  10. Ge F1, Lin H1, Liu Y1, Li M1, Guo R1, Ruan Z1, Chang T1. Dual antiplatelet therapy after stroke or transient ischaemic attack - how long to treat? The duration of aspirin plus clopidogrel in stroke or transient ischaemic attack: a systematic review and meta-analysis.. Eur J Neurol. 2016 Jun;23(6):1051-7. . pmid:27021849 PubMed  
  11. Lee M, Wu YL, Saver JL, Lee HC, Lee JD, Chang KC, Wu CY, Lee TH, Wang HH, Rao NM, Ovbiagele B. Is clopidogrel better than aspirin following breakthrough strokes while on aspirin? A retrospective cohort study. BMJ Open. 2014 Dec 2;4(12):e006672 . pmid:25468508 PubMed  
  12. Côté R1, Zhang Y, Hart RG, McClure LA, Anderson DC, Talbert RL, Benavente OR.. ASA failure: does the combination ASA/clopidogrel confer better long-term vascular protection?. Neurology. 2014; Feb 4;82(5):: 382-9. pmid:24384643 PubMed  
  13. Zheng AS, Churilov L, Colley RE, Goh C, Davis SM, Yan B. Association of aspirin resistance with increased stroke severity and infarct size. JAMA Neurol 2013; 70: 208-13. PMID: 23165316 PubMed  
  14. Reny JL, Berdagué P, Poncet A, Barazer I, Nolli S, Fabbro-Peray P, Schved JF, Bounameaux H, Mach F, de Moerloose P, Fontana P; Antiplatelet Drug Resistances and Ischemic Events (ADRIE) Study Group. Antiplatelet drug response status does not predict recurrent ischemic events in stable cardiovascular patients: results of the Antiplatelet Drug Resistances and Ischemic Events study. Circulation 2012; 25: 3201-10. Circulation  
  15. Wang Y, Johnston SC, Bath PM, Grotta JC, Pan Y, Amarenco P, Wang Y, Simon T, Kim JS, Jeng JS, Liu L, Lin Y, Wong KSL, Wang D, Li H. Acute dual antiplatelet therapy for minor ischaemic stroke or transient ischaemic attack. BMJ. 2019 Feb 28;364:l895. PMID: 30819687 PubMed  
  16. Dahabreh IJ, Moorthy D, Lamont JL, Chen ML, Kent DM, Lau J. Testing of CYP2C19 Variants and Platelet Reactivity for Guiding Antiplatelet Treatment Internet. Rockville (MD): Agency for Healthcare Research and Quality (US); 2013 Sep. PMID: 25165804 PubMed  
  17. Johansen H1, Rutherford OW2, Aamodt AH1, Russell D3, Atar D4, Ghanima W5.. New anticoagulants in combination with antiplatelet agents.. Tidsskr Nor Laegeforen. 2016 Oct 11;136(18):1543-1546 . pmid:27731598 PubMed  
  18. Wardlaw JM, Debette S, Jokinen H, De Leeuw FE, Pantoni L, Chabriat H, Staals J, Doubal F, Rudilosso S, Eppinger S, Schilling S, Ornello R, Enzinger C, Cordonnier C, Taylor-Rowan M, Lindgren AG. ESO Guideline on covert cerebral small vessel disease. Eur Stroke J. 2021 Jun;6(2):CXI-CLXII. doi: 10.1177/23969873211012132. Epub 2021 May 11. PMID: 34414301 PubMed  
  19. Søberg T. Protonpumpehemmer forebygger medikamentindusert blødende magesår. Tidsskr Nor Legeforen 2012; 132: 1208-9. Tidsskrift for Den norske legeforening  
  20. D'Anna L, Filippidis FT, Antony S, Brown Z, Wyatt H, Malik A, Sivakumaran P, Harvey K, Marinescu M, Bentley P, Korompoki E, Veltkamp R. Early initiation of direct anticoagulation after stroke in patients with atrial fibrillation. Eur J Neurol 2020. pmid:32542878. PubMed  
  21. Hong KS, Kwon SU, Lee SH, Lee JS, Kim YJ, Song TJ, Kim YD, Park MS, Kim EG, Cha JK, Sung SM, Yoon BW, Bang OY, Seo WK, Hwang YH, Ahn SH, Kang DW, Kang HG, Yu KH; Phase 2 Exploratory Clinical Study to Assess the Effects of Xarelto (Rivaroxaban) Versus Warfarin on Ischemia, Bleeding, and Hospital Stay in Acute Cerebral Infarction Patients With Non-valvular Atrial Fibrillation (Triple AXEL) Study Group. Rivaroxaban vs Warfarin Sodium in the Ultra-Early Period After Atrial Fibrillation-Related Mild Ischemic Stroke: A Randomized Clinical Trial.JAMA Neurol. 2017 Oct 1;74(10):1206-1215.PMID: 28892526 PubMed  
  22. Halvorsen S1, Ghanima W2, Tvete IF3, Hoxmark C4, Falck P5, Solli O5, Jonasson C6.. A nationwide registry study to compare bleeding rates in patients with atrial fibrillation being prescribed oral anticoagulants. Eur Heart J Cardiovasc Pharmacother. 2016. pmid:27680880 PubMed  
  23. Tsivgoulis G, Triantafyllou S, Palaiodimou L, Grory BM, Deftereos S, Köhrmann M, Dilaveris P, Ricci B, Tsioufis K, Cutting S, Magiorkinis G, Krogias C, Schellinger PD, Dardiotis E, Rodriguez-Campello A, Cuadrado-Godia E, Aguiar de Sousa D, Sharma M, Gladstone DJ, Sanna T, Wachter R, Furie KL, Alexandrov AV, Yaghi S, Katsanos AH. Prolonged Cardiac Monitoring and Stroke Recurrence: A Meta-analysis. Neurology. 2022 May 10;98(19):e1942-e1952. doi: 10.1212/WNL.0000000000200227. Epub 2022 Mar 9. PMID: 35264426. PubMed  
  24. Rubiera M, Aires A, Antonenko K, Lémeret S, Nolte CH, Putaala J, Schnabel RB, Tuladhar AM, Werring DJ, Zeraatkar D, Paciaroni M. European Stroke Organisation (ESO) guideline on screening for subclinical atrial fibrillation after stroke or transient ischaemic attack of undetermined origin. Eur Stroke J. 2022 Sep;7(3):VI. doi: 10.1177/23969873221099478. Epub 2022 Jun 3. PMID: 36082257 PubMed  
  25. Mach F, Baigent C, Catapano AL, Koskinas KC, Casula M, Badimon L, Chapman MJ, De Backer GG, Delgado V, Ference BA, Graham IM, Halliday A, Landmesser U, Mihaylova B, Pedersen TR, Riccardi G, Richter DJ, Sabatine MS, Taskinen MR, Tokgozoglu L, Wiklund O; ESC Scientific Document Group. Eur Heart J. 2019 Aug 31. pii: ehz455. PMID: 31504418 PubMed  
  26. Compter A, van der Worp HB, Schonewille WJ, Vos JA, Boiten J, Nederkoorn PJ, Uyttenboogaart M, Lo RT, Algra A, Kappelle LJ; VAST investigators. Stenting versus medical treatment in patients with symptomatic vertebral artery stenosis: a randomised open-label phase 2 trial. Lancet Neurol. 2015 Jun;14(6):606-14 . pmid:25908089 PubMed  
  27. Liu, Liping MD *; Wong, Ka Sing Lawrence MD *; Leng, Xinyi PhD; Pu, Yuehua MD; Wang, Yilong MD; Jing, Jing MD; Zou, Xinying MD; Pan, Yuesong MD; Wang, Anxin MS; Meng, Xia MD; Wang, Chunxue MD; Zhao, Xingquan MD; Soo, Yannie MD; Johnston, S. Claiborne MD; Wang, Yongjun MD; For the CHANCE Investigators. Dual antiplatelet therapy in stroke and ICAS: Subgroup analysis of CHANCE.. Neurology. 2015 Aug 28 . pmid:26330567 PubMed  
  28. Lutsep HL, Lynn MJ, Cotsonis GA, Derdeyn CP, Turan TN, Fiorella D, Janis LS, Lane BF, Montgomery J, Chimowitz MI; SAMMPRIS Investigators. Does the Stenting Versus Aggressive Medical Therapy Trial Support Stenting for Subgroups With Intracranial Stenosis?. Stroke. 2015 Nov;46(11):3282-4 . pmid:26382173 PubMed  
  29. Derdeyn CP, Chimowitz MI, Lynn MJ, Fiorella D, Turan TN, Janis LS, Montgomery J, Nizam A, Lane BF, Lutsep HL, Barnwell SL, Waters MF, Hoh BL, Hourihane JM, Levy EI, Alexandrov AV, Harrigan MR, Chiu D, Klucznik RP, Clark JM, McDougall CG, Johnson MD, Pride GL Jr, Lynch JR, Zaidat OO, Rumboldt Z, Cloft HJ; Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis Trial Investigators. Aggressive medical treatment with or without stenting in high-risk patients with intracranial artery stenosis (SAMMPRIS): the final results of a randomised trial. Lancet. 2014 Jan 25;383(9914):333-41 . pmid:24168957 PubMed  
  30. Tsivgoulis G1, Katsanos AH2, Magoufis G3, Kargiotis O3, Papadimitropoulos G4, Vadikolias K5, Karapanayiotides T6, Ellul J7, Alexandrov AW8, Mitsias PD9, Alexandrov AV10.. Percutaneous transluminal angioplasty and stenting for symptomatic intracranial arterial stenosis: a systematic review and meta-analysis.. Ther Adv Neurol Disord. 2016 Sep;9(5):351-8 . pmid:27582890 PubMed  
  31. Mir H, Siemieniuk RAC, Ge L, Foroutan F, Fralick M, Syed T, Lopes LC, Kuijpers T, Mas JL, Vandvik PO, Agoritsas T, Guyatt GH. Patent foramen ovale closure, antiplatelet therapy or anticoagulation in patients with patent foramen ovale and cryptogenic stroke: a systematic review and network meta-analysis incorporating complementary external evidence. BMJ Open. 2018 Jul 25;8(7):e023761. doi: 10.1136/bmjopen-2018-023761. Erratum in: BMJ Open. 2018 Aug 17;8(8):e023761corr1. PMID: 30049703 PubMed  
  32. Bala MM, Celinska-Lowenhoff M, Szot W, Padjas A, Kaczmarczyk M, Swierz MJ, Undas A.. Antiplatelet and anticoagulant agents for secondary prevention of stroke and other thromboembolic events in people with antiphospholipid syndrome.. Cochrane Database Syst Re 2020. pmid:28968483 PubMed  
  33. Boardman HM, Hartley L, Eisinga A, Main C, Roqué i Figuls M, Bonfill Cosp X, Gabriel Sanchez R, Knight B. Hormone therapy for preventing cardiovascular disease in post-menopausal women. Cochrane Database Syst Rev. 2015 Mar 10;3:CD002229 . pmid: 25754617 PubMed  
  34. Løkkegaard E, Nielsen LH, Keiding N. Risk of Stroke With Various Types of Menopausal Hormone Therapies: A National Cohort Study.Stroke. 2017 Aug;48(8):2266-2269. PMID: 28626058 PubMed  
  35. Messé SR, Gronseth GS, Kent DM, Kizer JR, Homma S, Rosterman L, Carroll JD, Ishida K, Sangha N, Kasner SE. . Practice advisory update summary: Patent foramen ovale and secondary stroke prevention: Report of the Guideline Subcommittee of the American Academy of Neurology. Neurology 2020. pmid:32350058 PubMed  
  36. Sharma M, Cornelius VR, Patel JP, Davies JG, Molokhia M. Efficacy and Harms of Direct Oral Anticoagulants in the Elderly for Stroke Prevention in Atrial Fibrillation and Secondary Prevention of Venous Thromboembolism: Systematic Review and Meta-Analysis. Circulation. 2015 Jul 21;132(3):194-204 . pmid:25995317 PubMed  
  37. Messé SR1, Gronseth G1, Kent DM1, Kizer JR1, Homma S1, Rosterman L1, Kasner SE1.. Practice advisory: Recurrent stroke with patent foramen ovale (update of practice parameter): Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology.. Neurology. 2016 Aug 23;87(8):815-21. . pmid: 27466464 PubMed  
  • Ole Morten Rønning, spesialist i nevrologi, professor dr med
  • Åse Mygland, spesialist i nevrologi, professor dr med
  • Unn Ljøstad, spesialist i nevrologi, professor, PhD

Tidligere fagmedarbeidere

  • Eivind Berge, spesialist i indremedisin og kardiologi, dr med