Hopp til hovedinnhold

Cerebral småkarsykdom

Sist oppdatert: Sist revidert:
Sist revidert av:
  1. Cannistraro RJ1, Badi M1, Eidelman BH1, Dickson DW1, Middlebrooks EH1, Meschia JF2. CNS small vessel disease: A clinical review. Neurology. 2019; Jun 11;92(24): 1146-1156. pmid:31142635 PubMed  
  2. Wardlaw JM, Smith C, Dichgans M.. Small vessel disease: mechanisms and clinical implications.. Lancet Neurol. 2019; Jul;18(7):: 684-696. pmid:31097385 PubMed  
  3. Tan RY, Drazyk AM, Urankar K, Bailey C, Gräf S, Markus H, Giffin NJ. Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL). Pract Neurol. 2021 Oct;21(5):448-451. doi: 10.1136/practneurol-2021-003058. Epub 2021 Aug 25. PMID: 34433685 PubMed  
  4. Ford AL, Chin VW, Fellah S, Binkley MM, Bodin AM, Balasetti V, Taiwo Y, Kang P, Lin D, Jen JC, Grand MG, Bogacki M, Liszewski MK, Hourcade D, Chen Y, Hassenstab J, Lee JM, An H, Miner JJ, Atkinson JP. Lesion evolution and neurodegeneration in RVCL-S: A monogenic microvasculopathy. Neurology. 2020 Oct 6;95(14):e1918-e1931. PMID: 32887784. PubMed  
  5. Mancuso M, Arnold M, Bersano A, Burlina A, Chabriat H, Debette S, Enzinger C, Federico A, Filla A, Finsterer J, Hunt D, Lesnik Oberstein S, Tournier-Lasserve E, Markus HS. Monogenic cerebral small-vessel diseases: diagnosis and therapy. Consensus recommendations of the European Academy of Neurology. Eur J Neurol. 2020 Jun;27(6):909-927. PMID: 32196841. PubMed  
  6. Pearce LA1, McClure LA2, Anderson DC3, Jacova C4, Sharma M5, Hart RG5, Benavente OR6; SPS3 Investigators.. Effects of long-term blood pressure lowering and dual antiplatelet treatment on cognitive function in patients with recent lacunar stroke: a secondary analysis from the SPS3 randomised trial. Lancet Neurol. 2014. pmid: 25453457 PubMed  
  7. Lavallée PC, Labreuche J, Gongora-Rivera F, Jaramillo A, Brenner D, Klein IF,. Placebo-controlled trial of high-dose atorvastatin in patients with severe small vessel disease. Stroke 2009; 40: 1721-8. Stroke  
  8. Guo Y, Li Y, Liu X, Cui Y, Zhao Y, Sun S, Jia Q, Chai Q, Gong G, Zhang H, Liu Z. Assessing the effectiveness of statin therapy for alleviating cerebral small vessel disease progression in people ≥75 years of age. BMC Geriatr. 2020 Aug 17;20(1):292. PMID: 32807086 PubMed  
  9. Al-Shahi Salman R, Minks DP, Mitra D, Rodrigues MA, Bhatnagar P, du Plessis JC, Joshi Y, Dennis MS, Murray GD, Newby DE, Sandercock PAG, Sprigg N, Stephen J, Sudlow CLM, Werring DJ, Whiteley WN, Wardlaw JM, White PM; . Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial. Lancet Neurol. 2019. pmid:31129065 PubMed  
  10. Wardlaw JM, Debette S, Jokinen H, De Leeuw FE, Pantoni L, Chabriat H, Staals J, Doubal F, Rudilosso S, Eppinger S, Schilling S, Ornello R, Enzinger C, Cordonnier C, Taylor-Rowan M, Lindgren AG. ESO Guideline on covert cerebral small vessel disease. Eur Stroke J. 2021 Jun;6(2):CXI-CLXII. doi: 10.1177/23969873211012132. Epub 2021 May 11. PMID: 34414301 PubMed  
  11. Best JG, Cardus B, Klijn CJM, Lip G, Seiffge DJ, Smith EE, Werring DJ. Antithrombotic dilemmas in stroke medicine: new data, unsolved challenges. J Neurol Neurosurg Psychiatry. 2022 Jun 21:jnnp-2020-325249. doi: 10.1136/jnnp-2020-325249. Epub ahead of print. PMID: 35728935. PubMed  
  12. Stretz C, Wu TY, Wilson D, Seiffge DJ, Smith EE, Gurol ME, Yaghi S. Ischaemic stroke in anticoagulated patients with atrial fibrillation. J Neurol Neurosurg Psychiatry. 2021 Nov;92(11):1164-1172. doi: 10.1136/jnnp-2020-323963. Epub 2021 Aug 26. PMID: 34446528. PubMed  
  13. Charidimou A, Shoamanesh A; International META-MICROBLEEDS Initiative. Clinical relevance of microbleeds in acute stroke thrombolysis: Comprehensive meta-analysis. Neurology. 2016 Oct 11;87(15):1534-1541. pmid:27629086 PubMed  
  14. Curtze S, Putaala J, Sibolt G, Melkas S, Mustanoja S, Haapaniemi E, Sairanen T, Tiainen M, Tatlisumak T, Strbian D. Cerebral white matter lesions and post-thrombolytic remote parenchymal hemorrhage. Ann Neurol. 2016 Oct;80(4):593-9 . pmid:27531598 PubMed  
  15. Charidimou A, Pasi M, Fiorelli M, Shams S, von Kummer R, Pantoni L, Rost N. Leukoaraiosis, Cerebral Hemorrhage, and Outcome After Intravenous Thrombolysis for Acute Ischemic Stroke: A Meta-Analysis (v1). Stroke. 2016 Sep;47(9):2364-72. doi: 10.1161/STROKEAHA.116.014096. Erratum in: Stroke. 2016 Oct;47(10):e244. PMID: . pmid:27491738 PubMed  
  16. Erkinjuntti T, Román G, Gauthier S. . Treatment of vascular dementia- evidence from clinical trials with cholinesterase inhibitors. J Neurol Sci 2004; 226: 63-6. pmid:15537522 PubMed  
  17. van Es AC, van der Grond J, de Craen AJ, Westendorp RG, Bollen EL, Blauw GJ, Greenberg SM, van Buchem MA; For the PROSPER Study Group. Cerebral microbleeds and cognitive functioning in the PROSPER study. Neurology 2011;77:1446-52. Neurology  
  18. Inzitari D, Pracucci G, Poggesi A, Carlucci G, Barkhof F, Chabriat H, Erkinjuntti T, Fazekas F, Ferro JM, Hennerici M, Langhorne P, O'Brien J, Scheltens P, Visser MC, Wahlund LO, Waldemar G, Wallin A, Pantoni L. Changes in white matter as determinant of global functional decline in older independent outpatients: three year follow-up of LADIS (leukoaraiosis and disability) study cohort. BMJ 2009; 339: b2477. BMJ (DOI)  
  19. Ghaznawi R, Geerlings MI, Jaarsma-Coes M, Hendrikse J, de Bresser J; UCC-Smart Study Group. Association of White Matter Hyperintensity Markers on MRI and Long-term Risk of Mortality and Ischemic Stroke: The SMART-MR Study. Neurology. 2021 Apr 27;96(17):e2172-e2183. doi: 10.1212/WNL.0000000000011827. Epub 2021 Mar 16. PMID: 33727406 PubMed  
  20. Kwan J, Hafdi M, Chiang LLW, Myint PK, Wong LS, Quinn TJ. Antithrombotic therapy to prevent cognitive decline in people with small vessel disease on neuroimaging but without dementia. Cochrane Database Syst Rev. 2022 Jul 14;7(7):CD012269. doi: 10.1002/14651858.CD012269.pub2. PMID: 35833913 PubMed  
  • Unn Ljøstad, spesialist i nevrologi, professor PhD
  • Åse Mygland, spesialist i nevrologi, professor dr med